ISI Journals

Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis and vascular abnormalities. Understanding the progression of SSc is crucial for developing effective treatments. This study employs Total Variation Diminishing (TVD) methods to model the dynamics of fibrosis in SSc, providing a detailed analysis of disease progression. Additionally, the research examines the impact of trade openness on healthcare access and outcomes, exploring how international trade policies can influence the availability of treatments for SSc patients. The paper includes a comprehensive literature review, detailed research methodology, results from the TVD method application, and conclusions on the implications for health policy and international trade.