Investigating the Role of CREB in Neuronal Plasticity using Systems Biology and the Izhikevich Model
World Journal of Technology and Scientific Research,
2023
Autour(s)
- Chang Li, Bing Pan, Zheng Xiang, Lixuan Zhang, Lee Chen, Don Chen
Abstract
The cyclic AMP response element-binding protein (CREB) is a transcription factor that plays a critical role in neuronal plasticity and memory formation. To better understand the complex molecular mechanisms underlying CREB-mediated plasticity, we employed systems biology approaches and the Izhikevich model to investigate the dynamics of neuronal firing patterns and synaptic plasticity. We utilized an optimization algorithm to estimate neuronal parameters and model the interactions between CREB and downstream targets. Our results provide insights into the molecular mechanisms underlying CREB-mediated plasticity and suggest potential therapeutic targets for memory-related disorders.